BAY 61-3606游离_化工百科

中文名	BAY 61-3606
英文名	BAY 61-3606
别名	BAY 61-3606游离 BAY 61-3606 游离碱 2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺
英文别名	CS-2745 BAY-61-360 BAY 61-3606 BAY 61-3606 free base Syk Inhibitor IV, BAY 61-3606 HCl BAY 61-3606 hydrate hydrochloride 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide
CAS	732983-37-8
化学式	C20H18N6O3
分子量	390.4
密度	1.41
溶解度	H2O: 可溶
存储条件	2-8°C
外观	固体
颜色	yellow
体外研究	BAY 61-3606 (0.01-10 μM ; 48 hours) significantly reduces the cell viability of SYK-positive SH-SY5Y and SYK-negative SK-N-BE cells in a dose-dependent matter. SH-SY5Y cells expressing high SYK levels are significantly more sensitive to BAY 61-3606 in comparison to SK-N-BEcells expressing very low or no SYK. BAY 61-3606 (0.4 and 0.8 μM; 4 or 24 hours) inhibits SYK activity by reducing ERK1/2 and Akt phosphorylation in neuroblastoma cell SH-SY5Y. BAY 61-3606 (2 μM; 2 hours) induces a large decrease of Syk phosphorylation in K-rn cell lysates. Cell Viability Assay Cell Line: SYK-positive SH-SY5Y and SYK-negative SK-N-BE cells Concentration: 0.01, 0.1, 1, and 10 μM Incubation Time: 48 hours Result: Significantly reduced the cell viability of both cell lines in a dose-dependent matter. Western Blot Analysis Cell Line: SH-SY5Y cells Concentration: 0.4 and 0.8 μM Incubation Time: 4 or 24 hours Result: Reduced the phosphorylation of ERK1/2 and Akt after a 4 or 24 h treatment. Western Blot Analysis Cell Line: K-rn cell lysates Concentration: 2 μM Incubation Time: 2 hours Result: Induced a large decrease of Syk phosphorylation.
体内研究	Bay 61-3606 (50 mg/kg; administered twice a week for two weeks by intraperitoneal injection) alone leads to more efficacious reductions than that of TNF-related apoptosis-inducing ligand (TRAIL; 10 mg/kg) alone in MCF-7 tumor xenograft-bearing BALB/c nude mice. Bay 61-3606 administered in TRAIL combination significantly reduces the volume of the xenografted tumor. Animal Model: Female BALB/c nude mice (5 weeks old) bearing MCF-7 tumor xenograft Dosage: 50 mg/kg Administration: Injected intraperitoneally twice a week with Bay 61-3606 (50 mg/kg), TRAIL (10 mg/kg) or a combination of Bay 61-3606 (50 mg/kg) and TRAIL (10 mg/kg); TRAIL was given 2 h after the injection of Bay 61-3606; for two weeks Result: Led to efficacious reductions in tumor growth.
WGK Germany	3

BAY 61-3606游离 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.562 ml	12.808 ml	25.615 ml
5 mM	0.512 ml	2.562 ml	5.123 ml
10 mM	0.256 ml	1.281 ml	2.562 ml
5 mM	0.051 ml	0.256 ml	0.512 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

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产品名: BAY 61-3606 去供应商网站查看询盘
CAS: 732983-37-8
产地: 北京
包装: 盒
规格: IB4460-5mg,5mg
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上海麦克林生化科技股份有限公司

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产品名: BAY 61-3606 去供应商网站查看询盘
CAS: 732983-37-8
产地: 上海
规格: B877604
价格: 10mg-1760,5mg-1000,50mg-7500
库存: 现货
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上海源叶生物科技有限公司

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产品名: BAY 61-3606 去供应商网站查看询盘
CAS: 732983-37-8
产地: 上海
规格: 98%
价格: 2mg 480,5mg 960,10mg 1760,25mg 3200,50mg 6000
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